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KMID : 0376219830200020287
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Chonnam Medical Journal
1983 Volume.20 No. 2 p.287 ~ p.295
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Antibacterial activities of fosfomycin singly or in combination with other antibiotics against penicillin-resistant Staphylococcus aureus.
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安泰然/Ahn, Tai Hew
金徹雄/辛富安/柳必悅/Kim, Chull Woong/Shin, Boo Ahn/Rhyu, Phil Youl
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Abstract
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Fosfomycin (FM) competes with phosphoenolpyruvate, an important building block for the first step in the synthesis of bacterial cell wall. Theoretically, therefore, FM kills bacteria by blocking the first step of bacterial cell wall formation. Fortunately, however, FM differs significantly from other cell wall active agents, showing neither allergic reaction nor antagonism with protein synthesis inhibitors.
FM has been introduced into our country recently. The present experiment was undertaken to evaluate the growth inhibitory effect of F M singly or in combination with other antibiotics against penicillin-resistant strains of Staphylococcus aurous isolated in our country.
Fifty strains of pathogenic Staphylococcus aurous isolated were submitted to the susceptibility test and the minimum inhibitory concentrations (NIIC) of each test antibiotic were measured. As expected, frequencies of resistant strains to penicillin (PC), ampicillin (AP), chloramphenicol (CM), gentamicin, and tetracycline were considerably high, while most strains were susceptible to cephaloridine.
It was noteworthy, however, that the isolation rate of strains revealing resistance to FM (MIC>8μg/ml) was also more than 50% in spite of the short period of its clinical application in our country.
Fifteen strains, which showed high degree of resistance to PC (MIC³32mg/ml were chosen among the strains and MICs of combined antibiotics, FM ? AP, FM CM, and Fri ? GLI, were determined against each of them through checkerboard dilution methods, checking MICs on isobolograms, and calculating fractional .inhibition concentration index. The results obtained were as follows:
FM ? AP combination exhibited additive effects generally, while both FM ? CM and FN I ? GM showing the same rate of synergism (25 %) and additive activity (75%). Unfavorable effects, such as indifference and antagonism were not observed.
Thus, it is suggested that F NI may be expected to have at least additive inhibitory effect on Slaplaylococcus aurous when applied together with AP, CM, or GM.
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